USP7
USP7 is a cysteine protease, belongs to the family of ubiquitin-specific proteases. USP7 was first discovered as a binding enzyme to the Herpes simplex viral protein. Studies have shown that USP7 could deubiquitinate the autoubiquitination of an E3
ligase called HDM2 that promotes ubiquitination and subsequent degradation of p53. The USP7/HDM2/p53 interaction results in higher protein levels of HDM2 and lower levels of p53. Because of its apparent role in different types of pathologies, including lung and liver cancer, it has become a possible target for drug therapies.
Product Name:
USP7
>Also Known As:
TEF1; HAUSP
>Catalog No.:
H5700
>Size:
25 µg
>Molecular Weight:
128.3 kDa
>Species:
Human
>Source:
Sf9 insect cells
>Stock:
20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
>Concentration:
See tube label
>Quality Assurance:
~90% by SDS-PAGE, see datasheet for gel image
>Storage:
Store at -80°C; avoid multiple freeze-thaw cycles
>PDF Data Sheet:
PDF Datasheet， MSDS
>NCBI RefSeq:
NM_003470
>Image(s):
N/A
>Shipping Method:
Dry ice shipping
>References:
1. Everett RD, et al. (1997) EMBO J 16(7), 1519 – 1530.
2. Li M, et al. (2004) Mol Cell 26(13), 879 – 886.
3. Cummins JM, et al (2004) Nature 428(6982), 1 p following 486.
4. Nicholson B, et al. (2011) Cell Biochem Biophys 60(1 – 2), 61 – 68. R428 18469180
