UMI-77
UMI-77 is a selective Mcl-1 inhibitor by binding of the BH3-binding groove of Mcl-1, by which it blocks the interactions of Bax/Mcl-1 and Bak/Mcl-1. UMI-77 inhibits growth of pancreatic cancer cells with IC50 of 3.4, 4.4, 12.5, 16.1, and 5.5 μM for BxPC-3, Panc-1, MiaPaCa-2, AsPC-1 and Capan-2 cells, respectively. UMI-77 induces apoptosis of various pancreatic cancer cell lines.
Product Name:
UMI-77
>Also Known As:
2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid
>Catalog No.:
F7150
>Size:
5 mg
>CAS:
518303-20-3
>Formula:
C18H14BrNO5S2
>Molecular Weight:
468.34 Da
>Form:
Lyophilized powder
>Quality Assurance:
>98% by HPLC and NMR
>Source:
Synthetic
>Storage:
Eligible for room temperature shipping. Store at -80°C upon receiving
>PDF Data Sheet:
Download PDF datasheet
>Image(s):
N/A
>Shipping Method:
Room temperature shipping
>References:
Abulwerdi F, et al. (2014) Mol Cancer Ther. 13(3), 565-575. GSK343 18481475
