SBI-0206965
SBI-0206965 is a potent inhibitor of the autophagy kinase ULK1. It inhibits ULK1 and ULK2 kinases with IC₅₀ of 108 nM and 711 nM, respectively. ULK1 is a serine/threonine kinase acting upsteam of PI3K to regulate the formation of autophagophores, the precursors of autophagosomes, in response to nutrient deprivation. SBI-0206965 suppresses ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival.
Product Name:
SBI-0206965
>Also Known As:
2-(5-bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yloxy)-N-methylbenzamide
>Catalog No.:
F6210
>Size:
5 mg
>CAS:
N/A
>Formula:
C21H21BrN4O5
>Molecular Weight:
489.32 Da
>Form:
Lyophilized powder
>Quality Assurance:
>98% by HPLC and NMR
>Source:
Synthetic
>Storage:
Eligible for room temperature shipping. Store at -80°C upon receiving
>PDF Data Sheet:
Download PDF datasheet
>Image(s):
N/A
>Shipping Method:
Room temperature shipping
>References:
Egan, DF, et al. (2015) Mol Cell 59 285-297. Napabucasin 18480974
