S5a
S5a is one of the integral Ub receptors of the 26S proteasome. It’s N-terminal vWA domain interacts with Rpn9 and Rpn10 on the 26S proteasome. The C-terminal domain of S5a contains two Ub-interacting motifs (UIMs) that bind Ub and Ub chains. S5a prefers to bind polyUb chains; it also binds proteins containing a Ub-like domain. It may directly recognize ubiquitinated proteins or coordinate with other Ub receptors to target substrates for proteasomal degradation.
Product Name:
S5a
>Also Known As:
PSMD4;AF; ASF; S5A; AF-1; MCB1; Rpn10; pUB-R5
>Catalog No.:
A3310
>Size:
25 µg
>Molecular Weight:
41.7 kDa
>Species:
Human
>Source:
Bacterial recombinant
>Stock:
20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
>Concentration:
See tube label
>Quality Assurance:
~90% by SDS-PAGE, see datasheet for gel image
>Storage:
Store at -80°C; avoid multiple freeze-thaw cycles
>PDF Data Sheet:
PDF Datasheet， MSDS
>NCBI RefSeq:
NM_002810
>Image(s):
(Click image to enlarge)
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Coomassie-stained SDS-PAGE Lane 1: Molecular weight markers Lane 2: 5 µg purified S5a |
>Shipping Method:
Dry ice shipping
>References:
1. Deveraux Q, et al. (1994) J Biol Chem 269(10), 7059 – 7061.
2. Beal R, et al. (1996) Proc Natl Acad Sci 93(2), 861 – 866.
3. Chen L, et al. (2002) Mol Cell Biol 22(13), 4902 – 4913.
4. Wang Q, et al. (2005) J Mol Biol 348, 727–739. SP2509 18482600
