Rapamycin
Rapamycin is an antifungal and immunosuppressant. Rapamycin was originally used an antifungal antibiotic. It is now known as a specific inhibitor of mTOR. Rapamycin binds to FK-binding protein 12 (FKBP12) and forms the rapamycin-FKBP12 complex, which regulates an enzyme that plays an important role in the progression of the cell cycle. Rapamycin and other inhibitors of mTORC1 signaling show potential in treating cancer, adipogenesis, diabetes, tuberous sclerosis, and cardiovascular disease.
Product Name:
Rapamycin
>Also Known As:
AY-22989, LCP-Siro, RAPA, Rapamune, Sirolimus, SILA 9268A
>Catalog No.:
F6130
>Size:
10 mg
>Molecular Weight:
914.17 Da
>Species:
N/A
>Source:
Synthetic
>Stock:
Powder
>Concentration:
N/A
>Quality Assurance:
>99% by HPLC and NMR
>Storage:
Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light
>PDF Data Sheet:
PDF Datasheet
>NCBI RefSeq:
N/A
>Image(s):
(Click image to enlarge)
Purity check of Rapamycin by HPLC
>Shipping Method:
Room temperature shipping
>References:
1. Corradetti MN, et al. (2006) Oncogene. 25(48):6347-60.
2. Foster KG, et al. (2010) J Biol Chem. 285(19):14071-7.
3. Malagelada C, et al. (2010) J Neurosci. 30(3):1166-75. SCH772984 18480205
