OTUB2
Deubiquitinating enzymes (DUBs) are proteases that posses the ability to cleave ubiquitin chains or the isopeptide bond that conjugates ubiquitin with a substrate. Human cells have approximately 100 DUBs that play important roles in regulating various cellular events. OTUB2 is a member of the ovarian tumor domain family. Not much is known about the biological function of this enzyme, but it may deubiquitinate TRAF3 and -6. This would negatively regulate virus-triggered type I IFN induction.
Product Name:
OTUB2
>Also Known As:
OTB2; OTU2; C14orf137
>Catalog No.:
H3100
>Size:
25 µg
>Molecular Weight:
27.2 kDa
>Species:
Human
>Source:
Bacterial recombinant
>Stock:
20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
>Concentration:
See tube label
>Quality Assurance:
~95% by SDS-PAGE, see datasheet for gel image
>Storage:
Store at -80°C; avoid multiple freeze-thaw cycles
>PDF Data Sheet:
PDF Datasheet， MSDS
>NCBI RefSeq:
NM_023112
>Image(s):
N/A
>Shipping Method:
Dry ice shipping
>References:
1. Balakirev MY, et al. (2003) EMBO Rep 4(5), 517 – 522.
2. Reyes-Turcu FE, et al. (2009) Annu Rev Biochem 78, 363 – 397.
3. Li S, et al. (2010) J Biol Chem 285(7), 4291 – 4297. CB-839 18468984
