GST-Sumo 2
SUMO (small Ub-related modifier) is a Ub-like protein. Three types of SUMO are most commonly studied, SUMO 1, SUMO 2, and SUMO 3. SUMO 2 and SUMO 3 are almost identical isoforms and thus share many functions. Like Ub, SUMO can be conjugated to its target proteins as a polymeric chain. However, SUMO 1 forms chains inefficiently as compared to SUMO 2 and SUMO 3. SUMO is conjugated to target proteins by the E1 (SAE1/SAE2), E2 (Ube2I or Ubc9), E3 (RanBP2/Nup358, amongst others). Protein sumoylation is involved in many cellular processes including gene transcription.
Product Name:
GST-Sumo 2
>Also Known As:
HSMT3; SMT3B; SUMO3; Smt3A; SMT3H2; MGC117191
>Catalog No.:
E3210
>Size:
500 µg
>Molecular Weight:
10.9 kDa
>Species:
Human
>Source:
Bacterial recombinant
>Stock:
20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
>Concentration:
See tube label
>Quality Assurance:
~90% by SDS-PAGE, see datasheet for gel image
>Storage:
Store at -80°C; avoid multiple freeze-thaw cycles
>PDF Data Sheet:
PDF Datasheet， MSDS
>NCBI RefSeq:
NM_006937
>Image(s):
N/A
>Shipping Method:
Dry ice shipping
>References:
1. Boddy MN, et al. (1996) Oncogene 13, 971 – 982.
2. Bayer P, et al. (1998) J Mol Biol 280, 275 – 286.
3. Melchior F, (2000) Annu Rev Cell Dev Biol 16, 591 – 626.
4. Praefcke GJK, et al. (2012) Trends Biochem Sci 37(1), 23 – 31.
5. Werner A, et al. (2012) Mol Cell 46(3), 287 – 298. LRRK2-IN-1 18478177
