GST-Ataxin3(Q22)
Ataxin3 is a Machado-Josephine domain-containing deubiquitinating enzyme. Machado–Joseph disease (MJD) is a neurodegenerative disorder caused by polyQ expansion in ataxin-3. Ataxin3 is involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates.
Product Name:
GST-Ataxin3(Q22)
>Also Known As:
ATXN3; AT3; JOS; MJD; ATX3; MJD1; SCA3
>Catalog No.:
H1610
>Size:
50 µg
>Molecular Weight:
41.2 kDa
>Species:
Human
>Source:
Bacterial recombinant
>Stock:
20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
>Concentration:
See tube label
>Quality Assurance:
~ 90% by SDS-PAGE
>Storage:
Store at -80°C; avoid multiple freeze-thaw cycles
>PDF Data Sheet:
PDF Datasheet， MSDS
>NCBI RefSeq:
NM_004993.5
>Image(s):
Images:
(Click image to enlarge)
 |
|
Coomassie-stained SDS-PAGE Lane 1: Molecular weight markers Lane 2: 5 µg purified GST-Ataxin3(Q22) |
>Shipping Method:
Dry ice shipping
>References:
1. Tzvetkov N, et al. (2007) Biol. Chem. 388:973-978
2. Li F, et al. (2002) J. Biol. Chem. 277:45004-45012
3. Winborn BJ, et al. (2008) J Biol Chem. 26;283(39):26436-43
BYL-719 18468822/
