6xHis-SENP8
Neural precursor cell expressed developmentally downregulated 8 (Nedd8) is a ubiquitin-like protein. Nedd8 can be conjugated on culin proteins and this modification plays a key role in activation of culin-based E3 ubiquitin ligases. SENP8 (also called NEDP1) is a cystein protease that specifically cleaves the Nedd8 precursor to generate mature Nedd8 and deconjugates neddylated proteins including culins and p53.
Product Name:
6xHis-SENP8
>Also Known As:
DEN1; NEDP1; PRSC2
>Catalog No.:
H9820
>Size:
25 µg
>Molecular Weight:
24.1 kDa
>Species:
Human
>Source:
Bacterial recombinant
>Stock:
20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
>Concentration:
See tube label
>Quality Assurance:
> 95% by SDS-PAGE, see datasheet for gel image
>Storage:
Store at -80°C; avoid multiple freeze-thaw cycles
>PDF Data Sheet:
PDF Datasheet， MSDS
>NCBI RefSeq:
NM_001166340.1
>Image(s):
(Click image to enlarge)
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Coomassie-stained SDS-PAGE Lane 1: Molecular weight markers Lane 2: 5 µg purified 6xHis-SENP8 |
>Shipping Method:
Dry ice shipping
>References:
1. Gan-Erdene T, et al. (2003) J Biol Chem. 278(31):28892-900.
2. Mendoza HM, et al. (2003) J Biol Chem. 278(28):25637-43. AZD9496 18469256
